If you no longer use Skype for Business or you launched the app by mistake, you’ll notice the app will continue to start with Windows 10, which can be annoying and a waste of resources.
Skype for Business comes integrated into the suite of Office apps, which means that it’ll not appear as a choice to uninstall it from the Settings app or Control Panel. However, you can disable the app permanently to prevent Skype from opening at startup on Windows 10.
How to disable Skype for Business on Windows 10
To uninstall (disable) Skype for Business, use these steps:
Open Skype for Business.
Click the Options menu (gear icon) from the top-right corner.
Click on Personal.
Under the “My account” section, clear the Automatically start the app when I log on to Windows option.
Clear the Start the app in the foreground option.
Click the OK button.
Once you complete the steps, the next time you restart your device, Skype for Business will no longer launch automatically and use system resources.